Ammonium formate → {[4-Hydroxy-1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carbonyl]-amino}-acetic acid

HRID 642473Notes

Reaction equation

HRID 642473 reaction equation
Br[C:2]1[N:18]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[C:5]2=[CH:6][N:7]=[C:8]([C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])[C:9]([OH:10])=[C:4]2[C:3]=1Br.C([O-])=O.[NH4+]>[Pd]>[OH:10][C:9]1[C:8]([C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])=[N:7][CH:6]=[C:5]2[N:18]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=3)[CH:2]=[CH:3][C:4]=12

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 68426300{[2,3-Dibromo-4-hydroxy-1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carbonyl]-amino}-acetic acid

Product 1

HCID 68427604{[4-Hydroxy-1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carbonyl]-amino}-acetic acid

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared in analogy to that of Example 6(a) from {[2,3-dibromo-4-hydroxy-1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carbonyl]-amino}-acetic acid, ammonium formate and Pd/C. The title compound, ESI MS (m/z): 356 (M+H)+.

Sources & evidence

ORD record
ord-cf93f6984bb5450f8208bc1f829103dc
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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