Acetic Anhydride → 4-Acetoxy-7-cyano-1-(4-methoxy-phenyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642490Notes

Reaction equation

HRID 642490 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:26])=[C:8]2[CH:16]=[CH:15][N:14](CC3C=CC(OC)=CC=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2].[C:27]([O:30][C:31](=O)[CH3:32])(=O)C>C(N(CC)CC)C>[CH2:1]([O:3][C:4]([C:6]1[C:7]([O:26][C:1](=[O:3])[CH3:2])=[C:8]2[CH:16]=[CH:15][N:14]([C:6]3[CH:4]=[CH:32][C:31]([O:30][CH3:27])=[CH:8][CH:7]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 68428970HCID 68428970, compound

Product 1

HCID 684261564-Acetoxy-7-cyano-1-(4-methoxy-phenyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Prepared in analogy to that of Example 120(a) from 7-cyano-4-hydroxy-1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, acetic anhydride, and triethyl amine. The title compound, ESI MS (m/z): 380 (M+H)+.

Sources & evidence

ORD record
ord-d2bf9ec03009446382a6d4be382295d0
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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