1-(Bromomethyl)naphthalene → 3-(2-Carboxy-ethyl)-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

HRID 642611Notes

Reaction equation

HRID 642611 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.Br[CH2:23][C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][CH:25]=1>>[C:17]([CH2:16][CH2:15][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=[CH:26][CH:25]=2)[C:6]=1[C:4]([OH:3])=[O:5])([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 612032Ethyl 3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate

Product 1

HCID 589002433-(2-Carboxy-ethyl)-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

Procedure

Using general procedure B, 3-(2-ethoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid ethyl ester was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 372.4 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-e15ffab94e4d4a77bfe2a8cb861628df
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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