1-(Bromomethyl)naphthalene → HCID 58900227, compound

HRID 642612Notes

Reaction equation

HRID 642612 reaction equation
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([C:13]=1[CH2:14][CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:4].Br[CH2:22][C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1>>[C:17]([CH2:16][CH2:15][CH2:14][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:22][C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=[CH:25][CH:24]=2)[C:5]=1[C:3]([OH:2])=[O:4])([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 68579658HCID 68579658, compound

Product 1

HCID 58900227HCID 58900227, compound

Procedure

3-(3-Carboxy-propyl)-1H-indole-2-carboxylic acid (Lit. 3) was esterified using HCl/MeOH to give the 3-(3-methoxycarbonyl-propyl)-1H-indole-2-carboxylic acid methyl ester. Using general procedure B, 3-(3-methoxycarbonyl-propyl)-1H-indole-2-carboxylic acid methyl ester was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 386.3 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-c40c7bfa10924128a10c33a4de17c6b5
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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