1-(Bromomethyl)naphthalene → 5-tert-Butyl-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

HRID 642623Notes

Reaction equation

HRID 642623 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:10][CH:9]=2)=[O:5])C.Br[CH2:20][C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][CH:22]=1>>[C:15]([C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:20][C:21]1[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=[CH:23][CH:22]=1)[C:6]([C:4]([OH:3])=[O:5])=[CH:14]2)([CH3:16])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 4714960ethyl 5-tert-butyl-1H-indole-2-carboxylate

Product 1

HCID 589003005-tert-Butyl-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

Procedure

Using general procedure B, 5-tert-butyl-1H-indole-2-carboxylic acid ethyl ester was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a pale brown solid. MS: 356.3 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-ae77c5223eaf4103b5d35c4303e5db33
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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