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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 642623Generated: October 27, 2026

1-(Bromomethyl)naphthalene → 5-tert-Butyl-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/642623

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)naphthaleneHCID 137844—
Reactantethyl 5-tert-butyl-1H-indole-2-carboxylateHCID 4714960—
Product5-tert-Butyl-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acidHCID 58900300—

Reaction Steps

Using general procedure B, 5-tert-butyl-1H-indole-2-carboxylic acid ethyl ester was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a pale brown solid. MS: 356.3 ([M−H]−).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07696240B2
Source datasetuspto-grants-2010_04
ORD IDord-ae77c5223eaf4103b5d35c4303e5db33
Source noteuspto-grants-2010_04