Piperidin-4-ol → HCID 58900294, compound

HRID 642643Notes

Reaction equation

HRID 642643 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=1)[C:6]1[C:22](=[O:27])[O:23][C:24](=[O:26])[CH2:25][C:5]2=1.[OH:28][CH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=1)[C:6]([C:22]([OH:23])=[O:27])=[C:5]2[CH2:25][C:24]([N:32]1[CH2:33][CH2:34][CH:29]([OH:28])[CH2:30][CH2:31]1)=[O:26]

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 86613188HCID 86613188, compound

Product 1

HCID 58900294HCID 58900294, compound

Procedure

6-Fluoro-9-naphthalen-1-ylmethyl-4,9-dihydro-pyrano[3,4-b]indole-1,3-dione (from example 34.1.) was ring opened with 4-hydroxypiperidine at 22° C. to give the title compound as a white solid. MS: 461.0 ([M+H]+).

Sources & evidence

ORD record
ord-e0ed30e066b44a748fd48a70eaaf454c
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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