1-(Bromomethyl)naphthalene → 1-Naphthalen-1-ylmethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

HRID 642678Notes

Reaction equation

HRID 642678 reaction equation
C([O:3][C:4]([C:6]1[NH:14][C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[CH:7]=1)=[O:5])C.Br[CH2:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1>>[C:17]1([CH2:16][N:14]2[C:9]3=[N:10][CH:11]=[CH:12][CH:13]=[C:8]3[CH:7]=[C:6]2[C:4]([OH:3])=[O:5])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 21868741Ethyl 1H-pyrrolo(2,3-b)pyridine-2-carboxylate

Product 1

HCID 446082591-Naphthalen-1-ylmethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Procedure

Using general procedure B, 1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester (Adams, David Reginald et al., PCT Int. Appl. (2000), WO2000044753) was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 301.3 ([M−H]−)

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-73bb9bac3fe94045b18c348f2278cb35
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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