3-Hydroxyazetidine → HCID 58900284, compound

HRID 642684Notes

Reaction equation

HRID 642684 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=1)[C:6]1[C:22](=[O:27])[O:23][C:24](=[O:26])[CH2:25][C:5]2=1.[NH:28]1[CH2:31][CH:30]([OH:32])[CH2:29]1>CCN(CC)CC>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=1)[C:6]([C:22]([OH:23])=[O:27])=[C:5]2[CH2:25][C:24]([N:28]1[CH2:31][CH:30]([OH:32])[CH2:29]1)=[O:26]

Participants

4

Reactant 2

HCID 15142903-HydroxyazetidineHCID 86613188HCID 86613188, compound

Product 1

HCID 58900284HCID 58900284, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

6-Fluoro-9-naphthalen-1-ylmethyl-4,9-dihydro-pyrano[3,4-b]indole-1,3-dione (from Example 68.1.) was ring opened with azetidin-3-ol and NEt3 at 22° C. to give the title compound as a white solid. MS: 431.3 ([M−H]−).

Sources & evidence

ORD record
ord-cc8126bcc8da498cb2fa5c3690d6817e
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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