Hydrochloric Acid → HCID 23581972, compound

HRID 642710Notes

Reaction equation

HRID 642710 reaction equation
C(OC(C1N(CC2C3C(=CC=C(F)C=3)C=CC=2)C2C(C=1CN)=CC=CC=2)=O)C.Cl.C([O:32][C:33]([C:35]1[N:36]([CH2:50][C:51]2[C:60]3[C:55](=[CH:56][CH:57]=[C:58]([F:61])[CH:59]=3)[CH:54]=[CH:53][CH:52]=2)[C:37]2[C:42]([C:43]=1[CH2:44][NH:45][C:46]([O:48][CH3:49])=[O:47])=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:34])C>>[F:61][C:58]1[CH:59]=[C:60]2[C:55]([CH:54]=[CH:53][CH:52]=[C:51]2[CH2:50][N:36]2[C:37]3[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:43]([CH2:44][NH:45][C:46]([O:48][CH3:49])=[O:47])=[C:35]2[C:33]([OH:34])=[O:32])=[CH:56][CH:57]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68578224HCID 68578224, compoundHCID 68578579HCID 68578579, compound

Product 1

HCID 23581972HCID 23581972, compound

Procedure

3-Aminomethyl-1-(7-fluoro-naphthalen-1-ylmethyl)-1H-indole-2-carboxylic acid ethyl ester; salt with HCl was converted to 1-(7-fluoro-naphthalen-1-ylmethyl)-3-(methoxycarbonylamino-methyl)-1H-indole-2-carboxylic acid ethyl ester as described in Example 77.1. which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give 1-(7-fluoro-naphthalen-1-ylmethyl)-3-(methoxycarbonylamino-methyl)-1H-indole-2-carboxylic acid as a white solid. MS: 405.5 ([M−H]−).

Sources & evidence

ORD record
ord-3429915519c1400da71ceb82e09c4aed
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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