Hydrochloric Acid → HCID 68577613, compound

HRID 642711Notes

Reaction equation

HRID 642711 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=3)[CH:22]=[CH:21][CH:20]=2)[C:8]2[C:13]([C:14]=1[CH2:15][NH:16][CH3:17])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])[CH3:2].Cl.Cl[C:32]([O:34][CH3:35])=[O:33]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([F:29])[CH:27]=3)[CH:22]=[CH:21][CH:20]=2)[C:8]2[C:13]([C:14]=1[CH2:15][N:16]([C:32]([O:34][CH3:35])=[O:33])[CH3:17])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6586Methyl chloroformateHCID 68580229HCID 68580229, compound

Product 1

HCID 68577613HCID 68577613, compound

Procedure

1-(7-Fluoro-naphthalen-1-ylmethyl)-3-methylaminomethyl-1H-indole-2-carboxylic acid ethyl ester; salt with HCl was reacted with methyl chloroformate as described in Example 77.1. to give 1-(7-fluoro-naphthalen-1-ylmethyl)-3-[(methoxycarbonyl-methyl-amino)-methyl]-1H-indole-2-carboxylic acid ethyl ester which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give 1-(7-fluoro-naphthalen-1-ylmethyl)-3-[(methoxycarbonyl-methyl-amino)-methyl]-1H-indole-2-carboxylic acid as a white solid. MS: 419.5 ([M−H]−).

Sources & evidence

ORD record
ord-599e9763f9eb4c5bb5b91cf2b1382cdc
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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