Hydrochloric Acid → HCID 68577686, compound

HRID 642713Notes

Reaction equation

Cl.[CH2:2]([O:4][C:5]([C:7]1[N:8]([CH2:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([F:34])[CH:32]=3)[CH:27]=[CH:26][CH:25]=2)[C:9]2[C:14]([C:15]=1[CH2:16][NH:17]S(C)(=O)=O)=[CH:13][C:12]([F:22])=[CH:11][CH:10]=2)=[O:6])[CH3:3]>>[CH2:2]([O:4][C:5]([C:7]1[N:8]([CH2:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([F:34])[CH:32]=3)[CH:27]=[CH:26][CH:25]=2)[C:9]2[C:14]([C:15]=1[CH2:16][NH2:17])=[CH:13][C:12]([F:22])=[CH:11][CH:10]=2)=[O:6])[CH3:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68577608HCID 68577608, compound

Product 1

HCID 68577686HCID 68577686, compound

Procedure

salt with HCl (prepared according to Example 104.2.) was converted to 5-fluoro-1-(7-fluoro-naphthalen-1-ylmethyl)-3-(methanesulfonylamino-methyl)-1H-indole-2-carboxylic acid ethyl ester as described in Example 77.1. which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a colorless solid. MS: 443.5 ([M−H]31 ).

Sources & evidence

ORD record: ord-ecd1be36c6014bab91e503afefdb28eb
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696240B2

Reaction notes

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