Hydrochloric Acid → HCID 68577686, compound

HRID 642715Notes

Reaction equation

Cl.[CH2:2]([O:4][C:5]([C:7]1[N:8]([CH2:25][C:26]2[C:35]3[C:30](=[CH:31][CH:32]=[C:33]([F:36])[CH:34]=3)[CH:29]=[CH:28][CH:27]=2)[C:9]2[C:14]([C:15]=1[CH2:16][N:17](C(OCC)=O)C)=[CH:13][C:12]([F:24])=[CH:11][CH:10]=2)=[O:6])[CH3:3]>>[CH2:2]([O:4][C:5]([C:7]1[N:8]([CH2:25][C:26]2[C:35]3[C:30](=[CH:31][CH:32]=[C:33]([F:36])[CH:34]=3)[CH:29]=[CH:28][CH:27]=2)[C:9]2[C:14]([C:15]=1[CH2:16][NH2:17])=[CH:13][C:12]([F:24])=[CH:11][CH:10]=2)=[O:6])[CH3:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68578601HCID 68578601, compound

Product 1

HCID 68577686HCID 68577686, compound

Procedure

salt with HCl (prepared according to Example 104.2.) was converted to 3-[(ethoxycarbonyl-methyl-amino)-methyl]-5-fluoro-1-(7-fluoro-naphthalen-1-ylmethyl)-1H-indole-2-carboxylic acid ethyl ester as described in Example 77.1. which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a white solid. MS: 451.5 ([M−H]−).

Sources & evidence

ORD record: ord-b7cb783497ad40eeb6f6e12830edd6ab
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696240B2

Reaction notes

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