Hydrochloric Acid → HCID 23582107, compound

HRID 642719Notes

Reaction equation

HRID 642719 reaction equation
C(OC(C1N(CC2C3C=C(F)C=CC=3SC=2)C2C(C=1CN)=CC=CC=2)=O)C.Cl.C([O:31][C:32]([C:34]1[N:35]([CH2:49][C:50]2[C:51]3[CH:58]=[C:57]([F:59])[CH:56]=[CH:55][C:52]=3[S:53][CH:54]=2)[C:36]2[C:41]([C:42]=1[CH2:43][NH:44][S:45]([CH3:48])(=[O:47])=[O:46])=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])C>>[F:59][C:57]1[CH:56]=[CH:55][C:52]2[S:53][CH:54]=[C:50]([CH2:49][N:35]3[C:36]4[C:41](=[CH:40][CH:39]=[CH:38][CH:37]=4)[C:42]([CH2:43][NH:44][S:45]([CH3:48])(=[O:47])=[O:46])=[C:34]3[C:32]([OH:33])=[O:31])[C:51]=2[CH:58]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68578208HCID 68578208, compoundHCID 68580610HCID 68580610, compound

Product 1

HCID 23582107HCID 23582107, compound

Procedure

3-Aminomethyl-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-1H-indole-2-carboxylic acid ethyl ester; salt with hydrogen chloride was converted to 1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-3-(methanesulfonylamino-methyl)-1H-indole-2-carboxylic acid ethyl ester as described in Example 77.1. which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give 1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-3-(methanesulfonylamino-methyl)-1H-indole-2-carboxylic acid as a colorless solid. MS: 431.3 ([M−H]−).

Sources & evidence

ORD record
ord-da8c76450f9c47b5b80fa2cd7d23139b
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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