Hydrochloric Acid → HCID 68578807, compound

HRID 642725Notes

Reaction equation

Cl.[CH2:2]([O:4][C:5]([C:7]1[N:8]([CH2:23][C:24]2[C:25]3[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:26]=3[S:27][CH:28]=2)[C:9]2[C:14]([C:15]=1[CH2:16][NH:17]C(OC)=O)=[CH:13][C:12]([F:22])=[CH:11][CH:10]=2)=[O:6])[CH3:3]>>[CH2:2]([O:4][C:5]([C:7]1[N:8]([CH2:23][C:24]2[C:25]3[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:26]=3[S:27][CH:28]=2)[C:9]2[C:14]([C:15]=1[CH2:16][NH2:17])=[CH:13][C:12]([F:22])=[CH:11][CH:10]=2)=[O:6])[CH3:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68578251HCID 68578251, compound

Product 1

HCID 68578807HCID 68578807, compound

Procedure

salt with hydrogen chloride (from Example 119.2.) was converted to 5-fluoro-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-3-(methoxycarbonylamino-methyl)-1H-indole-2-carboxylic acid ethyl ester as described in Example 77.1. which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a white solid. MS: 429.3 ([M−H]−).

Sources & evidence

ORD record: ord-b19ba289506746f790a95b541b03cfac
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696240B2

Reaction notes

Loading…