反应详情

To a solution of 2-methyl-3-nitro anisole which is commercially available (1a1) (5.1 g; 30.33 mmol; requires ˜30 min. to dissolve) in absolute ethanol (85 mL) was added 10% Pd/C catalyst (500 mg). The solution was hydrogenated under a hydrogen filled balloon at atmospheric pressure and room temperature for 19 h. The reaction mixture was filtered through a Celite pad, rinsed and evaporated to dryness to obtain the compound 1a2 as a deep mauve oil (4.1 g; 29.81 mmol; 98% yield). MS 137 (MH)+. Reverse Phase HPLC Homogeneity@220 nm (0.06% TFA; CH3CN; H2O): 99%.

1. customat atmospheric pressure and room temperature
2. customfor 19 h
3. filtrationThe reaction mixture was filtered through a Celite pad
4. washrinsed
5. customevaporated to dryness
6. customto obtain the compound 1a2 as a deep mauve oil (4.1 g; 29.81 mmol; 98% yield)