反应详情

To a stirred solution of compound 1F in dioxane (50 mL) and 2M KH2PO4 (50 mL) was added NaBH4 (1.0 g, 26.4 mmol) over a 10 min-period, and the stirring was continued at RT for 1 hr. The reaction mixture was diluted with 2M HCl to adjust pH to 1, and stirred at RT for another 1 hr. The reaction was concentrated, dissolved in EtOAc, washed with water, dried over Na2SO4, and concentrated. Purification by silica gel chromatography (50% EtOAc in hexanes) provided the title compound (1.9 g) as a pale yellow oil.

1. concentrationThe reaction was concentrated
2. dissolutiondissolved in EtOAc
3. washwashed with water
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customPurification by silica gel chromatography (50% EtOAc in hexanes)