tert-Butyldimethylsilyl chloride → HCID 59676079, compound

HRID 642766Notes

Reaction equation

HRID 642766 reaction equation
[CH:1]1[C:6]2[C:7]3[NH:8][C:9]4[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:10]=4[C:11]=3[CH2:12][CH2:13][S:14][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:20][C:21]([Si:24](Cl)([CH3:26])[CH3:25])([CH3:23])[CH3:22]>>[C:21]([Si:24]([CH3:26])([CH3:25])[O:19][C:16]1[CH:17]=[CH:18][C:9]2[NH:8][C:7]3[C:6]4[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=4[S:14][CH2:13][CH2:12][C:11]=3[C:10]=2[CH:15]=1)([CH3:23])([CH3:22])[CH3:20]

Participants

3

Reactant 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 59676100HCID 59676100, compound

Product 1

HCID 59676079HCID 59676079, compound

Procedure

Following the procedure described in Example 80, using 6,7-Dihydro-12H-5-thia-12-aza-dibenzo[a,e]azulen-9-ol (350 mg, 1.31 mmol) and TBSCl (225 mg, 1.50 mmol) as the starting material, the title compound was prepared as a white solid.

Sources & evidence

ORD record
ord-e65b785ba8d04a9ba9c5e0100d9c9967
Source dataset
uspto-grants-2010_04
Patent number
US07696239B2

Reaction notes

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