反应详情

To a solution of 1-bromo-4-nitro-benzene (2.02 g, 10 mmol) in toluene (20 mL) is added palladium tetrakis triphenylphosphine (1.156 g, 1 mmol), 4-t-butyl phenyl boronic acid (3.56 g, 20 mmol), and potassium fluoride (1.74 g, 30 mmol). The reaction is purged with nitrogen three times and heated to reflux under nitrogen. At the reflux temperature, water (5 mL) is added to the reaction and the reaction is allowed to reflux under nitrogen. The reaction is monitored by HPLC, and upon completion, allowed to cool to room temperature. The reaction is, diluted with ethyl acetate and Celite® is added, followed by water. This mixture is then filtered through a pad of Celite®. The solution is poured into a separatory funnel and the organic layer is washed with water and brine. The organic layer is dried over anhydrous sodium sulfate and concentrated. The resulting residue is purified by flash column chromatography, eluting with ethyl acetate/hexanes to afford 1.8 g of the product as a yellow solid. 1H-NMR.

1. customThe reaction is purged with nitrogen three times
2. temperatureheated
3. temperatureto reflux under nitrogen
4. additionAt the reflux temperature, water (5 mL) is added to the reaction
5. temperatureto reflux under nitrogen
6. additiondiluted with ethyl acetate and Celite®
7. additionis added
8. filtrationThis mixture is then filtered through a pad of Celite®
9. additionThe solution is poured into a separatory funnel
10. washthe organic layer is washed with water and brine
11. dry with materialThe organic layer is dried over anhydrous sodium sulfate
12. concentrationconcentrated
13. customThe resulting residue is purified by flash column chromatography
14. washeluting with ethyl acetate/hexanes