反应详情

4-[1-(4′-tert-Butyl-biphenyl-4-ylamino)-3-methyl-butyl]-benzoic acid methyl ester (718 mg) is taken into MeOH (10 mL), followed by the addition of 5N NaOH (1 mL). The reaction is stirred for 4 h, diluted with EtOAc, washed with aqueous HCl and brine. The organic portion is dried over MgSO4, and concentrated to afford 510 mg of the titled compound, which is used directly in the next step.

1. washwashed with aqueous HCl and brine
2. dry with materialThe organic portion is dried over MgSO4
3. concentrationconcentrated