Methanol → 3-{4-[1-(4'-tert-Butyl-biphenyl-4-ylamino)-3-methyl-butyl]-benzoylamino}-propionic acid

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Reaction Steps

3-{4-[1-(4′-tert-butyl-biphenyl-4-ylamino)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester (30 mg) is taken into MeOH (10 mL), followed by the addition of 5N NaOH (1 mL). The reaction is stirred for 4 h, diluted with EtOAc, washed with aqueous HCl, and brine. The organic portion is dried over MgSO4, and concentrated to afford 16 mg of the titled compound. MS (ES): 487.3 [M+H]+.

Provenance & Evidence