HRID642809

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)CCNC(=O)c1ccc(C(CC(C)C)Nc2ccc(-c3ccc(C(C)(C)C)cc3)cc2)cc1

HCID68578347

未命名化合物

PRODUCTS

生成物

结构：CC(C)CC(Nc1ccc(-c2ccc(C(C)(C)C)cc2)cc1)c1ccc(C(=O)NCCC(=O)O)cc1

HCID16738899

未命名化合物

收率 54.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

3-{4-[1-(4′-tert-butyl-biphenyl-4-ylamino)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester (30 mg) is taken into MeOH (10 mL), followed by the addition of 5N NaOH (1 mL). The reaction is stirred for 4 h, diluted with EtOAc, washed with aqueous HCl, and brine. The organic portion is dried over MgSO4, and concentrated to afford 16 mg of the titled compound. MS (ES): 487.3 [M+H]+.

WORKUP

后处理

washwashed with aqueous HCl, and brine
dry with materialThe organic portion is dried over MgSO4
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-152cf6baf7914a83aaf9ba5d465d1da9
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07696248B2
来源说明: uspto-grants-2010_04

反应 SMILES

C[O:2][C:3](=[O:37])[CH2:4][CH2:5][NH:6][C:7](=[O:36])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=3)=[CH:22][CH:21]=2)[CH2:15][CH:16]([CH3:18])[CH3:17])=[CH:10][CH:9]=1.CO.[OH-].[Na+]>CCOC(C)=O>[C:32]([C:29]1[CH:28]=[CH:27][C:26]([C:23]2[CH:24]=[CH:25][C:20]([NH:19][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:37])=[O:2])=[O:36])=[CH:9][CH:10]=3)[CH2:15][CH:16]([CH3:18])[CH3:17])=[CH:21][CH:22]=2)=[CH:31][CH:30]=1)([CH3:34])([CH3:35])[CH3:33]