反应详情

To a solution of (5-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-yl]-piperazin-1-ylmethyl}-2-nitro-phenyl)-pyridin-3-ylmethyl-amine (0.05 g, 0.087 mMol) in methanol (10 mL) under nitrogen was added platinum on carbon (0.034g, 0.0087 mMol) and the reaction mixture evacuated. A hydrogen filled balloon was attached and the mixture stirred under a hydrogen atmosphere for two hours. The balloon was removed, the flask purged with nitrogen, and the mixture filtered thru Celite with a large excess of methanol. The resulting solution was concentrated to dryness on a rotory evaporator to yield 4-{4-[2-(4-tert-Butyl-phenyl)-1H-benzoimidazol-4-yl]-piperazin-1-ylmethyl}-N2-pyridin-3-ylmethyl-benzene-1,2-diamine as a crude oil (0.047 g, 100% yield). LC/MS (Method A), rt=0.86 mins., purity=68%, calculated mass=545, [M+H]+=546, [M−H]−=544.

1. customthe reaction mixture evacuated
2. customThe balloon was removed
3. customthe flask purged with nitrogen
4. filtrationthe mixture filtered
5. concentrationThe resulting solution was concentrated to dryness on a rotory evaporator