HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzoic Acid → 4-Chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzoic Acid | HCID 6318 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)pyridin-2(1H)-one hydrochloride | HCID 66974101 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)benzamide | HCID 24987257 | 34.3% |
Reaction Steps
To a solution of 4-chlorobenzoic acid (40 mg, 0.26 mmol) and triethylamine (0.150 mL, 1.08 mmol) in DMF (2 mL), BOP (135 mg, 0.30 mmol) was added. After 5 min of stirring, 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)pyridin-2(1H)-one hydrochloride (53 mg, 0.18 mmol) was added. The mixture was stirred at room temperature for 2 h. It was then purified by HPLC to give the titled compound (25 mg). MS 405.1 and 407.1 (M+H, Cl pattern).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696352B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-4e7c5cc9f3944311b2d40e55d77e4b3e |
| Source note | uspto-grants-2010_04 |