反应详情

To a solution of 4-chlorobenzoic acid (40 mg, 0.26 mmol) and triethylamine (0.150 mL, 1.08 mmol) in DMF (2 mL), BOP (135 mg, 0.30 mmol) was added. After 5 min of stirring, 1-(4-(4-(aminomethyl)-1H-imidazol-1-yl)phenyl)pyridin-2(1H)-one hydrochloride (53 mg, 0.18 mmol) was added. The mixture was stirred at room temperature for 2 h. It was then purified by HPLC to give the titled compound (25 mg). MS 405.1 and 407.1 (M+H, Cl pattern).

1. stirringThe mixture was stirred at room temperature for 2 h
2. customIt was then purified by HPLC