Methanol → HCID 24988738, compound

HRID 643016Notes

Reaction equation

HRID 643016 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C:11]2[N:12]=[N:13][N:14]([C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH2:29][CH2:30][S:31][CH3:32])[C:23]4=[O:33])=[CH:18][CH:17]=3)[CH:15]=2)=[O:8])=[CH:4][CH:3]=1.CO.[OH:36]OS([O-])=O.[K+]>O>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C:11]2[N:12]=[N:13][N:14]([C:16]3[CH:17]=[CH:18][C:19]([N:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH2:29][CH2:30][S:31]([CH3:32])=[O:36])[C:23]4=[O:33])=[CH:20][CH:21]=3)[CH:15]=2)=[O:8])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 23707502Potassium hydroxy sulfiteHCID 24988737HCID 24988737, compound

Product 1

HCID 24988738HCID 24988738, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of Example 48 in a 2:1 mixture of methanol and water was added 1.0 equivalent of oxone. The mixture was stirred at room temperature for 10 min and directly subjected to reverse phase HPLC to isolate the title compound as a white powder after lyophilization. MS found for C22H20ClN5O4S2 (M+H)+ 518.1, 520.1 (Cl pattern).

Sources & evidence

ORD record
ord-75a022621c0b4099ab329f5b268dd174
Source dataset
uspto-grants-2010_04
Patent number
US07696352B2

Reaction notes

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