Methanol → HCID 24988739, compound

HRID 643017Notes

Reaction equation

HRID 643017 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C:11]2[N:12]=[N:13][N:14]([C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH2:29][CH2:30]SC)[C:23]4=[O:33])=[CH:18][CH:17]=3)[CH:15]=2)=[O:8])=[CH:4][CH:3]=1.[CH3:34]O.O[O:37][S:38]([O-:40])=O.[K+]>O>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C:11]2[N:12]=[N:13][N:14]([C:16]3[CH:17]=[CH:18][C:19]([N:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH2:29][CH2:30][S:38]([CH3:34])(=[O:40])=[O:37])[C:23]4=[O:33])=[CH:20][CH:21]=3)[CH:15]=2)=[O:8])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 23707502Potassium hydroxy sulfiteHCID 24988737HCID 24988737, compound

Product 1

HCID 24988739HCID 24988739, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of Example 48 in a 2:1 mixture of methanol and water was added 3 equivalent of oxone. The mixture was stirred at room temperature for 1 hr and directly subjected to reverse phase HPLC to isolate the title compound as a white powder after lyophilization. MS found for C22H20ClN5O5S2 (M+H)+ 534.1, 536.1 (Cl pattern).

Sources & evidence

ORD record
ord-e9e9340c90ad49f48f030c8025d4197f
Source dataset
uspto-grants-2010_04
Patent number
US07696352B2

Reaction notes

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