反应详情

A solution of 4-iodoaniline (0.684 g, 3.12 mmol) and 2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde (90%, 0.492 mL, 3.12 mmol) in HOAc (10 mL) was stirred at 90° C. for 1 h. The solvent was removed in vacuo. The residue was partitioned between EtOAc and H2O. The organic phase was separated, washed with 5% NaHCO3, dried over Na2SO4, and concentrated in vacuo to give 1-(4-iodophenyl)-1H-pyrrole-3-carbaldehyde (0.927 g).

1. customThe solvent was removed in vacuo
2. customThe residue was partitioned between EtOAc and H2O
3. customThe organic phase was separated
4. washwashed with 5% NaHCO3
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo