反应详情

温度

25 °C

To a solution of Example 28A (12.1 g) in methanol (20 mL) was added L-isoleucine tert-butyl ester hydrochloride (13.0 g, 58 mmol), sodium cyanoborohydride (7.3 g, 116 mmol), and acetic acid (2 mL). The resulting solution was stirred for 3 hrs at 25° C. and the methanol removed under vacuum, dichloromethane (500 mL) added, and the solution washed with aqueous NaHCO3 (2×300 mL). The organic layer was concentrated to give 12.9 g of the title compound.

1. customthe methanol removed under vacuum, dichloromethane (500 mL)
2. additionadded
3. washthe solution washed with aqueous NaHCO3 (2×300 mL)
4. concentrationThe organic layer was concentrated