反应详情

温度

70 °C

To a solution of Example 28B (12.9 g) in ethanol (400 mL) was added hydrazine hydrate (11.2 mL). The solution was then heated to 70° C. for 2 hrs. After cooling to 25° C., the resulting solid was dissolved in 1N NaOH solution (200 mL) and water (200 mL). The solution was then extracted with dichloromethane (3×200 mL), the organic extracts combined, dried and evaporated to provide 6.8 g of the title compound.

1. temperatureAfter cooling to 25° C.
2. extractionThe solution was then extracted with dichloromethane (3×200 mL)
3. customdried
4. customevaporated