Ethyl 4-amino-3-bromo-5-chlorobenzoate → 4-Amino-3-bromo-5-chlorobenzoic acid

HRID 643138Notes

Reaction equation

HRID 643138 reaction equation
[NH2:1][C:2]1[C:12]([Cl:13])=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][C:3]=1[Br:14]>Cl.CCO>[NH2:1][C:2]1[C:12]([Cl:13])=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[Br:14]

Participants

4

Reactant 1

HCID 28820670Ethyl 4-amino-3-bromo-5-chlorobenzoate

Product 1

HCID 288206724-Amino-3-bromo-5-chlorobenzoic acid

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

A solution of 21.0 g (75.4 mmol) ethyl 4-amino-3-bromo-5-chloro-benzoate in 200 mL 4 M HCl and 100 mL EtOH was refluxed overnight. After cooling the precipitate formed was suction filtered and dried.

Workup

  1. temperatureAfter cooling the precipitate
  2. customformed
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-c395370c4f31448db0ea7eb55f0855cb
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

Loading…