Lithium Hydroxide → (R)-2-(4-benzyloxy-3,5-dimethyl-phenyl)-1-carboxy-ethyl 4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

HRID 643162Notes

Reaction equation

HRID 643162 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]([O:22][C@@H:23]([C:41]([O:43]C)=[O:42])[CH2:24][C:25]4[CH:30]=[C:29]([CH3:31])[C:28]([O:32][CH2:33][C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)=[C:27]([CH3:40])[CH:26]=4)=[O:21])[CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:45]=1.[Li+].[OH-]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:15][CH2:16][N:17]([C:20]([O:22][C@@H:23]([C:41]([OH:43])=[O:42])[CH2:24][C:25]4[CH:26]=[C:27]([CH3:40])[C:28]([O:32][CH2:33][C:34]5[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=5)=[C:29]([CH3:31])[CH:30]=4)=[O:21])[CH2:18][CH2:19]3)[CH2:9][CH2:8][C:7]=2[CH:45]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68675980HCID 68675980, compound

Product 1

HCID 68675621(R)-2-(4-benzyloxy-3,5-dimethyl-phenyl)-1-carboxy-ethyl 4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

Procedure

Prepared analogously to Example 21b from 0.65 g (1.06 mmol) (R)-2-(4-benzyloxy-3,5-dimethyl-phenyl)-1-methoxycarbonyl-ethyl 4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 38.4 mg (1.60 mmol) LiOH.

Sources & evidence

ORD record
ord-f19578e1a0b546eb890796542dcf1027
Source dataset
uspto-grants-2010_04
Patent number
US07696209B2

Reaction notes

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