2-Chloro-3-(trifluoromethyl)benzyl alcohol → 3-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluoromethyl)benzyl]oxy}phenyl)cinnoline

HRID 643333Notes

Reaction equation

HRID 643333 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[N:9][C:8](C1C=CC=CC=1)=[C:7]2[C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1.[Cl:25][C:26]1[C:31]([C:32]([F:35])([F:34])[F:33])=[CH:30][CH:29]=[CH:28][C:27]=1[CH2:36]O>>[CH2:7]([C:8]1[N:9]=[N:10][C:11]2[C:6]([C:7]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:36][C:27]3[CH:28]=[CH:29][CH:30]=[C:31]([C:32]([F:35])([F:34])[F:33])[C:26]=3[Cl:25])[CH:19]=1)=[CH:5][CH:4]=[CH:3][C:2]=2[Cl:1])[C:6]1[CH:11]=[CH:2][CH:3]=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 27781082-Chloro-3-(trifluoromethyl)benzyl alcoholHCID 118564393-(8-Chloro-3-phenylcinnolin-4-yl)phenol

Product 1

HCID 118545703-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluoromethyl)benzyl]oxy}phenyl)cinnoline

Procedure

The title compound was prepared from 3-(8-chloro-3-phenyl-cinnolin-4-yl)-phenol and (2-chloro-3-trifluoromethyl-phenyl)-methanol according the procedure of Example 55. MS (ES) m/z 538.7.

Sources & evidence

ORD record
ord-fdd125169da84219aab81fefb14c11c6
Source dataset
uspto-grants-2010_04
Patent number
US07700595B2

Reaction notes

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