Hydrochloric Acid → HCID 178434251, compound

HRID 643347Notes

Reaction equation

HRID 643347 reaction equation
[NH2:1][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[C@@H:10]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:9]2)=[N:6][C:5]([C:28]2[CH:29]=[C:30]3[C:34](=[CH:35][CH:36]=2)[NH:33][N:32]=[C:31]3[CH3:37])=[CH:4][N:3]=1.Cl>ClCCl.O1CCOCC1>[NH2:1][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][NH:11][C@@H:10]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:9]2)=[N:6][C:5]([C:28]2[CH:29]=[C:30]3[C:34](=[CH:35][CH:36]=2)[NH:33][N:32]=[C:31]3[CH3:37])=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178434253HCID 178434253, compound

Product 1

HCID 178434251HCID 178434251, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-amino-3-[(S)-4-Boc-3-benzylpiperazinyl]-5-(3-methyl-1H-indazol-5-yl)pyrazine 109 (20 mg, 0.04 mmol) in dichloromethane (2 mL) was added a 4 M solution of HCl in dioxane (2 mL). The reaction mixture was stirred at room temperature for 1 hour. The organic solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 2-amino-3-[(S)-3-benzylpiperazinyl]-5-(3-methyl-1H-indazol-5-yl)pyrazine 110 (12 mg, 0.03 mmol).

Workup

  1. customThe organic solvent was evaporated under reduced pressure
  2. customThe crude product was purified by RP-HPLC

Sources & evidence

ORD record
ord-db0d6f7894e24722be463e0eb2eaef38
Source dataset
uspto-grants-2010_04
Patent number
US07700601B2

Reaction notes

Loading…