反应详情

2-[(S)-4-Boc-3-benzylpiperazinyl]-6-[3-methyl-1-(trimethylsilyl)ethoxymethyl-1H-indazol-5-yl]pyrazine 118 (0.115 g, 0.187 mmol) was dissolved in a 90% aqueous trifloroacetic acid solution (10 mL). The reaction mixture was stirred at room temperature for 16 hours. The solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 2-[(S)-3-benzylpiperazinyl]-6-[3-methyl-1H-indazol-5-yl]pyrazine 119 (0.072 g, 0.187 mmol).

1. customThe solvent was evaporated under reduced pressure
2. customThe crude product was purified by RP-HPLC