HCID 68579161, compound → Cysteine Protease inhibitor

HRID 643497Notes

Reaction equation

HRID 643497 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[N:23]=3)[CH:16]=2)=[CH:11][CH:10]=1)(C)(C)C>C(O)=O>[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[N:23]=3)[CH:16]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 68579161HCID 68579161, compound

Product 1

HCID 12000657Cysteine Protease inhibitor

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of [3′-(2-cyano-pyrimidin-4-yloxy)-biphenyl-4-ylmethyl]-carbamic acid tert-butyl ester (10 mg) in formic acid (0.154 ml) is stirred at rt for 1 h. This solution is evaporated under reduced pressure. The remaining oil is treated with diethyl ether to obtain crystals of 4-(4′-aminomethyl-biphenyl-3-yloxy)-pyrimidine-2-carbonitrile as salt with formic acid.

Workup

  1. customThis solution is evaporated under reduced pressure
  2. additionThe remaining oil is treated with diethyl ether

Sources & evidence

ORD record
ord-c73d254753694664a3b2da5a0731dd8b
Source dataset
uspto-grants-2010_04
Patent number
US07700605B2

Reaction notes

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