HCID 68580868, compound → HCID 15981170, compound

HRID 643501Notes

Reaction equation

HRID 643501 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]3[N:27]=[C:26]([C:28]#[N:29])[N:25]=[CH:24][N:23]=3)[CH:16]=2)=[CH:11][CH:10]=1)(C)(C)C>C(O)=O>[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]3[N:23]=[CH:24][N:25]=[C:26]([C:28]#[N:29])[N:27]=3)[CH:16]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 68580868HCID 68580868, compound

Product 1

HCID 15981170HCID 15981170, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of [3′-(4-cyano-[1,3,5]triazin-2-ylamino) -biphenyl-4-ylmethyl]-carbamic acid tert-butyl ester (43 mg) in formic acid (1 ml) is stirred at 5° C. for 4.5 h. This solution is evaporated under reduced pressure. The remaining oil is treated with diethyl ether to obtain crystals of 4-(4′-aminomethyl-biphenyl-3-ylamino)-[1,3,5]triazine-2-carbonitrile, salt with formic acid.

Workup

  1. customThis solution is evaporated under reduced pressure
  2. additionThe remaining oil is treated with diethyl ether

Sources & evidence

ORD record
ord-ad91e6c3920a45c1bc34c44a481f3bbc
Source dataset
uspto-grants-2010_04
Patent number
US07700605B2

Reaction notes

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