Hydrochloric Acid → Ethyl 3-piperidin-4-ylbenzoate hydrochloride

HRID 643535Notes

Reaction equation

HRID 643535 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1)=[O:5])[CH3:2].[ClH:25]>O1CCOCC1>[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12]([C:8]2[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=2)[C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57880576Tert-butyl 4-[3-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate

Product 1

HCID 66973363Ethyl 3-piperidin-4-ylbenzoate hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-[3-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate (3.24 g, 9.72 mmol) was dissolved in anhydrous 4N HCl in dioxane (ca. 30 mL) and stirred at rt for 1.5 h. The reaction mixture was concentrated to give ethyl 3-piperidin-4-ylbenzoate hydrochloride as a pale yellow solid that required no further purification.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-75c3dbf0c4264182ab65aef09220a9dd
Source dataset
uspto-grants-2010_04
Patent number
US07700591B2

Reaction notes

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