Hydrochloric Acid → HCID 68536030, compound

HRID 643558Notes

Reaction equation

HRID 643558 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:21]([O:23][CH3:24])=[O:22].[ClH:25]>O1CCOCC1>[ClH:25].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:21]([O:23][CH3:24])=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57880551HCID 57880551, compound

Product 1

HCID 68536030HCID 68536030, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-[4-fluoro-3-(methoxycarbonyl)phenyl]piperidine-1-carboxylate (471 mg, 1.40 mmol) was dissolved in anhydrous 4N HCl in dioxane (5 mL) and stirred at rt for 40 min. The reaction mixture was concentrated to afford methyl 2-fluoro-5-piperidin-4-ylbenzoate hydrochloride which was used without further purification. ESI-MS calc. for C13H16FNO2: 237; Found: 238 (M+H).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d024a573bbbe42b785c28f8e2b24749c
Source dataset
uspto-grants-2010_04
Patent number
US07700591B2

Reaction notes

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