(1S)-N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxamide → (1S)-1-Isopropyl-3-{4-[3-(methoxycarbonyl)phenyl]piperidin-1-yl}cyclopentane carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	(1S)-N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxamide	HCID 58617139	—
Reactant	Methyl 3-(1-{(3S)-3-[(benzyloxy)carbonyl]-3-isopropylcyclopentyl}piperidin-4-yl)benzoate	HCID 58617156	—
Product	(1S)-1-Isopropyl-3-{4-[3-(methoxycarbonyl)phenyl]piperidin-1-yl}cyclopentane carboxylic acid	HCID 58617140	—

Reaction Steps

(1S)-1-Isopropyl-3-{4-[3-(methoxycarbonyl)phenyl]piperidin-1-yl}cyclopentane carboxylic acid was synthesized as described for INTERMEDIATE 3 (procedure A, step F) using methyl 3-(1-{(3S)-3-[(benzyloxy)carbonyl]-3-isopropylcyclopentyl}piperidin-4-yl)benzoate as starting material. The desired was obtained as a 10:1 mixture of cis: trans around the cyclopentane ring.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700591B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-53f357c5d18148e7a6144037c839078e
Source note	uspto-grants-2010_04