Hydrochloric Acid → HCID 67301161, compound

HRID 643586Notes

Reaction equation

HRID 643586 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C@@H:11]([OH:15])[C:12]([OH:14])=[O:13])[CH:6]=[CH:7][C:8]=1[Cl:9].[CH3:16][CH2:17]O>>[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C@@H:11]([OH:15])[C:12]([O:14][CH2:16][CH3:17])=[O:13])[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 67301399HCID 67301399, compound

Product 1

HCID 67301161HCID 67301161, compound

Procedure

50 mL ethanolic HCl were added to a solution of 3.5 g (14.9 mmol) of (R)-3-(3,4-dichloro-phenyl)-2-hydroxy-propionic acid in 50 mL EtOH and the reaction mixture was stirred for 4 h at RT. The reaction solution was evaporated down i. vac., the residue was combined with DCM, extracted with 15% K2CO3 solution and the organic phase was dried over Na2SO4. After the desiccant and solvent had been eliminated the product was obtained as an oil, which was further reacted without purification.

Workup

  1. customThe reaction solution was evaporated down i
  2. extractionextracted with 15% K2CO3 solution
  3. dry with materialthe organic phase was dried over Na2SO4
  4. customwas obtained as an oil, which
  5. customwas further reacted without purification

Sources & evidence

ORD record
ord-c46d9bc0e3154ed485ff62b3bad28e10
Source dataset
uspto-grants-2010_04
Patent number
US07700598B2

Reaction notes

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