Hydrochloric Acid → HCID 57266273, compound

HRID 643598Notes

Reaction equation

HRID 643598 reaction equation
C(N[C:5](=[CH:10][C:11]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=1)[C:6]([O:8]C)=[O:7])(=O)C.Cl.[O:26]1CCOCC1>>[F:22][C:21]([F:24])([F:23])[C:13]1[CH:12]=[C:11]([CH2:10][C:5](=[O:26])[C:6]([OH:8])=[O:7])[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86632301HCID 86632301, compound

Product 1

HCID 57266273HCID 57266273, compound

Conditions

Temperature
100 °C

Procedure

19.5 g (54.9 mmol) methyl 2-acetylamino-3-(3,5-bis-trifluoromethyl-phenyl)-acrylate in 100 mL 1,4-dioxane were heated to 100° C. bath temperature, combined with 100 mL 4 M HCl and stirred for 8 h at 100° C. bath temperature. The reaction mixture was evaporated down i. vac., the crystals were suction filtered, washed with water and dried in the drying cupboard at 50° C.

Workup

  1. customThe reaction mixture was evaporated down i
  2. filtrationfiltered
  3. washwashed with water
  4. customdried in the drying cupboard at 50° C.

Sources & evidence

ORD record
ord-5806aa8d2f64492e97495b59e58fa0e0
Source dataset
uspto-grants-2010_04
Patent number
US07700598B2

Reaction notes

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