Hydrochloric Acid → HCID 57529484, compound

HRID 643621Notes

Reaction equation

HRID 643621 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C@@H:11]([O:33][C:34]([N:36]2[CH2:41][CH2:40][CH:39]([N:42]3[CH2:48][CH2:47][C:46]4[CH:49]=[CH:50][CH:51]=[CH:52][C:45]=4[NH:44][C:43]3=[O:53])[CH2:38][CH2:37]2)=[O:35])[C:12]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)[CH2:16][CH2:15]2)=[O:13])[CH:6]=[CH:7][C:8]=1[CH3:9]>CO>[O:53]=[C:43]1[N:42]([CH:39]2[CH2:40][CH2:41][N:36]([C:34]([O:33][C@H:11]([CH2:10][C:5]3[CH:6]=[CH:7][C:8]([CH3:9])=[C:3]([Cl:2])[CH:4]=3)[C:12](=[O:13])[N:14]3[CH2:19][CH2:18][CH:17]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[CH2:16][CH2:15]3)=[O:35])[CH2:37][CH2:38]2)[CH2:48][CH2:47][C:46]2[CH:49]=[CH:50][CH:51]=[CH:52][C:45]=2[NH:44]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67301886HCID 67301886, compound

Product 1

HCID 57529484HCID 57529484, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 mL 1 M HCl were added to a solution of 130 mg (0.14 mmol) tert-butyl 4-(1-{(R)-3-(3-chloro-4-methyl-phenyl)-2-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyloxy]-propionyl}-piperidin-4-yl)-piperazine-1-carboxylate (Example 99) in 1 mL MeOH and the reaction mixture was stirred for 24 h at RT.

Sources & evidence

ORD record
ord-a7b3244b25c141868d41f5435f097cd8
Source dataset
uspto-grants-2010_04
Patent number
US07700598B2

Reaction notes

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