HCID 67301612, compound → HCID 57529626, compound

HRID 643627Notes

Reaction equation

HRID 643627 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([O:41][C:42]([N:44]2[CH2:49][CH2:48][CH:47]([N:50]3[CH2:56][CH2:55][C:54]4[CH:57]=[CH:58][CH:59]=[CH:60][C:53]=4[NH:52][C:51]3=[O:61])[CH2:46][CH2:45]2)=[O:43])[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([N:18]3[CH2:23][CH2:22][N:21](C(OCC4C5C=CC=CC=5C5C4=CC=CC=5)=O)[CH2:20][CH2:19]3)[CH2:14][CH2:13]2)=[O:11])=[CH:4][CH:3]=1>N1CCCCC1>[O:61]=[C:51]1[N:50]([CH:47]2[CH2:48][CH2:49][N:44]([C:42]([O:41][C@H:9]([CH2:8][C:5]3[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=3)[C:10](=[O:11])[N:12]3[CH2:17][CH2:16][CH:15]([N:18]4[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]4)[CH2:14][CH2:13]3)=[O:43])[CH2:45][CH2:46]2)[CH2:56][CH2:55][C:54]2[CH:57]=[CH:58][CH:59]=[CH:60][C:53]=2[NH:52]1

Participants

3

Reactant 1

HCID 67301612HCID 67301612, compound

Product 1

HCID 57529626HCID 57529626, compound

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

A solution of 250 mg (0.30 mmol) 9H-fluoren-9-ylmethyl 4-(1-{(R)-3-(4-hydroxyphenyl)-2-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyloxy]-propionyl}-piperidin-4-yl)-piperazine-1-carboxylate (Example 123) in 4 mL piperidine was stirred for 30 min at RT. The reaction mixture was evaporated down i.vac. and the residue was purified by chromatography (silica gel, DCM/MeOH/NH3 90:10:1).

Workup

  1. customThe reaction mixture was evaporated down i.vac
  2. customand the residue was purified by chromatography (silica gel, DCM/MeOH/NH3 90:10:1)

Sources & evidence

ORD record
ord-60857a9f78af47c0bcf0edcd42cf93c2
Source dataset
uspto-grants-2010_04
Patent number
US07700598B2

Reaction notes

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