Hydrazine → 4-Bromo-2-hydrazinylpyridine
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](F)[CH:3]=1.[NH2:9][NH2:10].[OH-].[Na+]>O>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:9][NH2:10])[CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A mixture of 4-bromo-2-fluoropyridine (8.67 g, 49.3 mmol) and anhydrous hydrazine (16.00 ml, 501 mmol) was heated at 70° C. for 2.5 h. The reaction was cooled to RT, basified with 5N NaOH and diluted with 60 mL of water. The precipitate was filtered, washed with water and dried in vacuo at 50° C. to give 6.80 g of the title compound as a white amorphous solid.
Workup
- temperatureThe reaction was cooled to RT
- filtrationThe precipitate was filtered
- washwashed with water
- customdried in vacuo at 50° C.
Sources & evidence
- ORD record
- ord-fee6b11399c040788d853e052dd11f55
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700593B2
Reaction notes
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