Hydrazine → 4-Bromo-2-hydrazinylpyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-bromo-2-fluoropyridine (8.67 g, 49.3 mmol) and anhydrous hydrazine (16.00 ml, 501 mmol) was heated at 70° C. for 2.5 h. The reaction was cooled to RT, basified with 5N NaOH and diluted with 60 mL of water. The precipitate was filtered, washed with water and dried in vacuo at 50° C. to give 6.80 g of the title compound as a white amorphous solid.

Provenance & Evidence