反应详情

温度

70 °C

To a suspension of 1-(4-bromopyridin-2-yl)hydrazine (0.710 g, 3.78 mmol) in 10 mL of 2-propanol was added cyanogen bromide (0.400 g, 3.78 mmol) at 25° C. The reaction was heated at 70° C. for 2 h and the reaction was monitored by LCMS. Additional cyanogen bromide (0.060 g) was added and the reaction was continued for another 2 h. The reaction was filtered while hot and the solid was washed with 2-propanol and pentane, and dried in vacuo to give the title compounds as a light orange amorphous solid. MS m/z: 214.9 [M+1].

1. filtrationThe reaction was filtered while hot and the solid
2. washwas washed with 2-propanol and pentane
3. customdried in vacuo