反应详情

温度

60 °C

4-Amino-2-methylmercaptopyrimidine-5-carboxylate (1.5 g, 7 mmol) was suspended in the solution of lithium hydroxide (340 mg, 14 mmol) in methanol (10 mL) and water (5 mL) and stirred at 60° C. over night. Solid was filtered out and filtrate was collected. Solvent was removed under reduce pressure. Residue was dissolved in water and was neutralized by acetic acid till pH˜5. White solid thus formed was filtered out and dried in vacuo (0.72 g, 55%).

1. filtrationSolid was filtered out
2. customfiltrate was collected
3. customSolvent was removed
4. dissolutionResidue was dissolved in water
5. customWhite solid thus formed
6. filtrationwas filtered out
7. customdried in vacuo (0.72 g, 55%)