反应详情

温度

95 °C

To a solution the (2-Amino-4-bromo-phenyl)-phenyl-methanone (276 mg, 1.0 mmol) and N-Cyclopropyl-3-iodo-4-methyl-benzamide (301 mg, 1.0 mmol) in 5 mL of methyl sulfoxide was added potassium carbonate (276 mg, 2.0 mmol) and followed by Pd(PPh3)4 (58 mg, 0.05 mmol). After the reaction mixture was stirred at 95° C. for 4 hours, the reaction mixture was allowed to cool to room temperature and 10 mL of water was added to the mixture. The resulting mixture was extracted with ethyl acetate (3×50 mL). The combined organic layers washed with water (10 mL) and brine (10 mL), dried over MgSO4, and the solvents were evaporated. The residue was purified by chromatography (hexanes:ethyl acetate=1:1) to give the desired compound as a colorless solid (180 mg, 49%).

1. temperatureto cool to room temperature
2. extractionThe resulting mixture was extracted with ethyl acetate (3×50 mL)
3. washThe combined organic layers washed with water (10 mL) and brine (10 mL)
4. dry with materialdried over MgSO4
5. customthe solvents were evaporated
6. customThe residue was purified by chromatography (hexanes:ethyl acetate=1:1)