HCID 55138170, compound → HCID 61229239, compound

HRID 643700Notes

Reaction equation

HRID 643700 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N+:13]([O-])=O)[C:5]([NH:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1>CO.[Pt]>[Br:1][C:2]1[CH:3]=[C:4]([NH2:13])[C:5]([NH:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1

Participants

4

Reactant 1

HCID 55138170HCID 55138170, compound

Product 1

HCID 61229239HCID 61229239, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-N-(cyclopropylmethyl)-3-nitropyridin-2-amine (Step C, 5.5 g, 20.3 mmol) and 3% platinum on sulfide carbon (N.E.CHEMCAT, 1 g) in methanol (250 mL) was stirred at room temperature for 3 h under hydrogen. The mixture was filtered through a pad of celite and the filtrate was concentrated to afford the title compound (4.9 g, 100%) as black oil.

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-875f536e8b72493098bdad7316a33ef6
Source dataset
uspto-grants-2010_04
Patent number
US07700618B2

Reaction notes

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